Hyperbaric oxygenation in rehabilitation medicine: application, action mechanisms, and effectiveness
https://doi.org/10.17749/2949-5873/rehabil.2025.38
Abstract
Modern medicine has achieved substantial progress in the treatment of diseases previously considered incurable. In this regard, a serious problem is posed for academia, i.e., to restore patients’ lost health. One of the medical technologies contributing to a pos- sible solution to this problem is hyperbaric oxygenation. This treatment method has been used in medicine for a long time and is considered one of the most effective means for patients’ treatment and rehabilitation within complex therapy. The literature review presents historical aspects of the development and implementation of hyperbaric oxygenation, mechanisms of its therapeutic effect, and the equipment it needs as well as provides updated data on its indications, contraindications, safety, and effectiveness.
About the Authors
N. F. Miryutova
Tomsk Research Institute of Balneology and Physiotherapy – Branch of Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency
Russian Federation
Russian Federation
Natalia F. Miryutova, Dr. Sci. Med., Prof.
1 Roza Luxemburg Str., Tomsk 634009
D. A. Gruzdeva
Sechenov University
Russian Federation
Russian Federation
Daria А. Gruzdeva
8/2 Trubetskaya Str., Moscow 119048
References
1. Zuenkova Yu.A. Organizational aspects of multidisciplinary teams: quality standards, efficiency and implementation in practice. Meditsinskoe obrazovanie i professional’noe razvitie / Medical Education and Professional Development. 2022; 13 (3): 32–42 (in Russ.). https://doi.org/10.33029/2220-8453-2022-13-3-32-41.
2. Ampilogova D.M., Solopova A.G., Blinov D.V., et al. The impact of rehabilitation on the quality of life of patients with vulvovaginal atrophy. Obstetrics, Gynecology and Reproduction. 2024; 18 (3): 338–51 (in Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2024.537.
3. Koryagina Yu.V., Ter-Akopov G.N., Nopin S.V. Possibilities of using hyperbaric oxygen therapy in biomedical support of high performance sport during intense training in middle altitude (analytical review). Modern Issues of Biomedicine. 2023; 7 (1): 28 (in Russ.). https://doi.org/10.51871/2588-0500_2023_07_01_28.
4. Petrikov S.S., Evseev A.K., Levina O.A., et al. Hyperbaric oxygen therapy in patients with COVID-19. General Reanimatology. 2020; 16 (6): 4–18 (in Russ.). https://doi.org/10.15360/1813-9779-2020-6-4-18.
5. Polozova E.V., Shilov V.V., Bogaсheva A.S., Davydova E.V. Evaluation of the effectiveness of hyperbaric oxygenation in acute carbon monoxide poisoning. Toxicological Review. 2016; 3: 33–5 (in Russ.). https://doi.org/10.36946/0869-7922-2016-3-33-35.
6. Miskin B.M., Fox L.A., Abou-Al-Shaar H., et al. Hyperbaric oxygen therapy for the management of mild and moderate traumatic brain injury: a single-center experience. World Neurosurg. 2023; 176: e357–70. https://doi.org/10.1016/j.wneu.2023.05.062.
7. Li X., Lu L., Min Y., et al. Efficacy and safety of hyperbaric oxygen therapy in acute ischaemic stroke: a systematic review and meta-analysis. BMC Neurology. 2024; 24 (1): 55. https://doi.org/10.1186/s12883-024-03555-w.
8. Smolle C., Lindenmann J., Kamolz L., Smolle-Juettner F.M. The history and development of hyperbaric oxygenation (HBO) in thermal burn injury. Medicina. 2021; 57 (1): 49. https://doi.org/10.3390/medicina57010049.
9. Levere T.H. Dr. Thomas Beddoes (1750–1808): science and medicine in politics and society. Br J Hist Sci. 1984; 17 (56 Pt 2): 187–204. https://doi.org/0.1017/s0007087400020914.
10. DDRC Healthcare. History of HBO. Available at: https://www.ddrc.org/hyperbarics/history-of-hbo/ (accessed 28.11.2024).
11. Ninokawa S., Nordham K. Discovery of caisson disease: a dive into the history of decompression sickness. Proc (Bayl Univ Med Cent). 2021; 35 (1): 129–32. https://doi.org/.1080/08998280.2021.1967021.
12. Ortega M.A., Fraile-Martinez O., García-Montero C., et al. A general overview on the hyperbaric oxygen therapy: applications, mechanisms and translational opportunities. Medicina. 2021; 57 (9): 864. https://doi.org/10.3390/medicina57090864.
13. Choudhury R. Hypoxia and hyperbaric oxygen therapy: a review. Int J Gen Med. 2018; 11: 431–42. https://doi.org/10.2147/IJGM.S172460.
14. Cannellotto M., Duarte M., Keller G., et al. Hyperbaric oxygen as an adjuvant treatment for patients with COVID-19 severe hypoxaemia: a randomised controlled trial. Emerg Med J. 2022; 39 (2): 88–93. https://doi.org/:10.1136/emermed-2021-211253.
15. Rossignol D.A. Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis. Medical Gas Research. 2012; 2 (1): 6. https://doi.org/10.1186/2045-9912-2-6.
16. Kolchina E.J., Bagaev V.G., Nalbandjan R.T. Hyperbaric oxygenation in treatment of wound infections. Wounds and Wound Infections. The prof. B.M. Kostyuchenok Journal. 2016; 3 (3): 20–5 (in Russ.). https://doi.org/10.17650/2408-9613-2016-3-3-20-25.
17. Yildiz H., Senol L., Ercan E., et al. A prospective randomized controlled trial assessing the efficacy of adjunctive hyperbaric oxygen therapy in the treatment of hidradenitis suppurativa. Int J Dermatol. 2016; 55 (2): 232–7. https://doi.org/10.1111/ijd.12936.
18. Malone M., Bjarnsholt T., McBain A.J., et al. The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data. J Wound Care. 2017; 26 (1): 20–5. https://doi.org/10.12968/jowc.2017.26.1.20.
19. Kalns J., Lane J., Delgado A., et al. Hyperbaric oxygen exposure temporarily reduces Mac-1 mediated functions of human neutrophils. Immunol Lett. 2002; 83 (2): 125–31. https://doi.org/10.1016/s0165-2478(02)00068-8.
20. Almzaiel A.J., Billington R., Smerdon G., Moody A.J. Effects of hyperbaric oxygen treatment on antimicrobial function and apoptosis of differentiated HL-60 (neutrophil-like) cells. Life Sci. 2013; 93 (2-3): 125–31. https://doi.org/10.1016/j.lfs.2013.06.003.
21. Thom S.R. Hyperbaric oxygen – its mechanisms and efficacy. Plast Reconstr Surg. 2011; 127 (Suppl. 1): 131S–41S. https://doi.org/.1097/PRS.0b013e3181fbe2bf.
22. Wang Y., Ni P., Zhuang D., et al. Early hyperbaric oxygen therapy through regulating the HIF-1α signaling pathway attenuates Neuroinflammation and behavioral deficits in a mouse model of sepsis-associated encephalopathy. J Neuroimmunol. 2024; 391: 578367. https://doi.org/10.1016/j.jneuroim.2024.578367.
23. Parra R.S., Lopes A.H., Carreira E.U., et al. Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats. Med Gas Res. 2015; 5 (1): 6. https://doi.org/10.1186/s13618-015-0026-2.
24. Akalaev R.N., Borisova E.M., Evdokimov E.A., et al. Hyperbaric medicine: the history of formation and path of development. The Bulletin of Emergency Medicine. 2014; 1: 85–94 (in Russ.).
25. Samoilov A.S., Udalov Yu.D., Sheyanov M.V., et al. Experience in applying hyperbaric oxygen therapy using portable pressure chambers for the treatment of patients with the novel coronavirus infection COVID-19. Journal Biomed. 2020; 2: 39–46 (in Russ.). https://doi.org/10.33647/2074-5982-16-2-39-46.
26. Fife C.E., Eckert K.A., Carter M.J. An update on the appropriate role for hyperbaric oxygen: indications and evidence. Plast Reconstr Surg. 2016; 138 (3 Suppl.): 107S–16S. https://doi.org/10.1097/PRS.0000000000002714.
27. Bennett M.H., Mitchell S.J. Emerging indications for hyperbaric oxygen. Curr Opin Anaesthesiol. 2019; 32 (6): 792–8. https://doi.org/10.1097/ACO.0000000000000773.
28. Levchenko P.A., Rychagov G.P. Results of conservative treatment of bedsores in patients with spinal trauma using hyperbaric oxygenation. Medical Journal. 2008; 3: 54–6 (in Russ.).
29. Nik Hisamuddin N.A.R., Wan Mohd Zahiruddin W.N., Mohd Yazid B., Rahmah S. Use of hyperbaric oxygen therapy (HBOT) in chronic diabetic wound – a randomised trial. Med J Malaysia. 2019; 74 (5): 418–24.
30. Martusevich A.K., Korotkova N.L., Peretyagin P.V., Zagrekov V.I. Influence of hyperbaric oxygenation on the state of microcirculation in patients recovering from burn injuries. Trudnyy patsient. 2020;18 (11–12): 40–3 (in Russ.).
31. Nenashev A.A. The developed highly effective method of treating patients with anaerobic infection is not subject to oblivion. Medical & Pharmaceutical Journal “Pulse”. 2007; 9 (1): 42–4 (in Russ.).
32. Levett D.Z., Bennett M.H., Millar I. Adjunctive hyperbaric oxygen for necrotizing fasciitis. Cochrane Database Syst Rev. 2015; 2015 (1): CD007937. https://doi.org/10.1002/14651858.CD007937.pub2.
33. Dean S.M., Werman H. Calciphylaxis: a favorable outcome with hyperbaric oxygen. Vasc Med. 1998; 3 (2): 115–20. https://doi.org/10.1177/1358836X9800300205.
34. Ahmed R., Severson M.A., Traynelis V.C. Role of hyperbaric oxygen therapy in the treatment of bacterial spinal osteomyelitis. J Neurosurg Spine. 2009; 10 (1): 16–20. https://doi.org/10.3171/2008.10.SPI08606.
35. Oscarsson N., Müller B., Rosén A., et al. Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): a randomised, controlled, phase 2–3 trial. Lancet Oncol. 2019; 20 (11): 1602–14. https://doi.org/10.1016/S1470-2045(19)30494-2.
36. Cooper J.S., Hanley M.E. Hyperbaric treatment of radiation proctitis. In: Treasure Island (FL): StatPearls Publishing; 2025 Jan. Available at: https://www.ncbi.nlm.nih.gov/books/NBK537343/ (accessed 03.02.2025).
37. Vasiliev I.T., Mumladee R.B., Yakushin V.I., et al. Treatment of patients with abdominal sepsis in the intensive care unit of a multidisciplinary hospital (part 2). Mоscоw Surgical Journal. 2014; 4: 5–15 (in Russ.).
38. Kerimova H.S. The role of hyperpressure oxygenation in the syndrome of prolonged compression (SDS) of the upper limb (case case). Scientific News of Academy of Physical Education and Sport. 2021; 3 (4): 63–6 (in Russ.). https://doi.org/10.28942/ssj.v3i4.394.
39. Miike T., Sakamoto Y., Sakamoto Y., et al. Influence of hyperbaric oxygen therapy on thrombus formation ability in humans.Undersea Hyperb Med. 2020; 47 (4): 591–5. https://doi.org/10.22462/10.12.2020.8.
40. Hendriksen S., Cooper J.S. Hyperbaric treatment of central retinal artery occlusion. In: Treasure Island (FL): StatPearls Publishing; 2025 Jan. Available at: http://www.ncbi.nlm.nih.gov/books/NBK431074/ (accessed 03.02.2025).
41. Robins M., Hendriksen S., Cooper J.S. Hyperbaric management of frostbite. In: Treasure Island (FL): StatPearls Publishing; 2025 Jan. Available at: http://www.ncbi.nlm.nih.gov/books/NBK448115/ (accessed 03.02.2025).
42. Shields R.C. Hyperbaric oxygen therapy for critical limb ischemia. In: Dieter R.S., Dieter R.A. Jr., Dieter R.A. III, Nanjundappa A. (Eds). Critical limb ischemia: acute and chronic. Springer; 2017: 483–9. https://doi.org/10.1007/978-3-319-31991-9_43.
43. Grebenyuk A.N., Bykov V.N. Carbon monoxide: modern concepts to the treatment of acute poisonings (literature review). Toxicological Review. 2021; 29 (5): 17–24 (in Russ.). https://doi.org/10.36946/0869-7922-2021-29-5-17-24.
44. Lawson-Smith P., Jansen E.C., Hilsted L., et al. Effect of acute and delayed hyperbaric oxygen therapy on cyanide whole blood levels during acute cyanide intoxication. Undersea Hyperb Med. 2011; 38 (1): 17–26.
45. Sun Q., Sun M., Zhang Y., et al. Clinical characteristics of methanol-induced optic neuropathy: correlation between aetiology and clinical findings. J Ophthalmol. 2022; 2022: 4671671. https://doi.org/10.1155/2022/4671671.
46. Zilberman-Itskovich S., Catalogna M., Sasson E., et al. Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial. Sci Rep. 2022; 12 (1): 11252. https://doi.org/10.1038/s41598-022-15565-0.
47. Efrati S., Golan H., Bechor Y., et al. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome – prospective clinical trial. PLoS One. 2015; 10 (5): e0127012. https://doi.org/10.1371/journal.pone.0127012.
48. Akarsu S., Tekin L., Ay H., et al. The efficacy of hyperbaric oxygen therapy in the management of chronic fatigue syndrome. Undersea Hyperb Med. 2013; 40 (2): 197–200.
49. DuBose K.J., Cooper J.S. Hyperbaric patient selection. In: Treasure Island (FL): StatPearls Publishing; 2025 Jan. Available at: http://www.ncbi.nlm.nih.gov/books/NBK499820/ (accessed 03.02.2025).
50. Feldmeier J., Carl U., Hartmann K., Sminia P. Hyperbaric oxygen: does it promote growth or recurrence of malignancy? Undersea Hyperb Med. 2003; 30 (1): 1–18.
51. Gawdi R., Cooper J.S. Hyperbaric contraindications. In: Treasure Island (FL): StatPearls Publishing; 2025 Jan. Available at: http://www.ncbi.nlm.nih.gov/books/NBK557661/ (accessed 03.02.2025).
52. Konda P., Holley M., Lakshmanan V.K. Role of hyperbaric oxygen therapy in prostate tumor microenvironment and cancer stem cell niche. Ann Urol Oncol. 2024; 7 (4): 185–94. https://doi.org/10.32948/auo.2024.12.01.
53. Ivashkov V.U., Sopromadze S.V., Dokolin R.M., et al. Application of hyperbaric oxygenation in the treatment of complications after reconstructive surgery in oncology. Bone and Soft Tissue Sarcomas, Tumors of the Skin. 2022; 1: 46–51 (in Russ.).
54. Heyboer M., Sharma D., Santiago W., McCulloch N. Hyperbaric oxygen therapy: side effects defined and quantified. Adv Wound Care. 2017; 6 (6): 210–24. https://doi.org/10.1089/wound.2016.0718.
55. Jain K.K. Textbook of hyperbaric medicine. Hogrefe & Huber Pub; 2009: 578 pp.
56. Shupak A., Gilbey P. Effects of pressure. In: Neuman T.S., Thom S.R. (Eds) Physiology and medicine of hyperbaric oxygen therapy. Saunders; 2008: 513–26.
57. Camporesi E.M. Side effects of hyperbaric oxygen therapy. Undersea Hyperb Med. 2014; 41 (3): 253–7.
58. Skevas T., Baumann I., Bruckner T., et al. Medical and surgical treatment in divers with chronic rhinosinusitis and paranasal sinus barotrauma. Eur Arch Otorhinolaryngol. 2012; 269 (3): 853–60. https://doi.org/10.1007/s00405-011-1742-4.
59. Stoetzer M., Kuehlhorn C., Ruecker M., et al. Pathophysiology of barodontalgia: a case report and review of the literature. Case Rep Dent. 2012; 2012: 453415. https://doi.org/10.1155/2012/453415.
60. Robichaud R., McNally M.E. Barodontalgia as a differential diagnosis: symptoms and findings. J Can Dent Assoc. 2005; 71 (1): 39–42.
61. Cakmak T., Battal B., Kara K., et al. A case of tension pneumothorax during hyperbaric oxygen therapy in an earthquake survivor with crush injury complicated by ARDS (adult respiratory distress syndrome). Undersea Hyperb Med. 2015; 42 (1): 9–13.
62. Unsworth I.P. Case report. Pulmonary barotrauma in a hyperbaric chamber. Anaesthesia. 1973; 28 (6): 675–8. https://doi.org/10.1111/j.1365-2044.1973.tb00555.x.
63. Lambertsen C.J., Dough R.H., Cooper D.Y., et al. Oxygen toxicity; effects in man of oxygen inhalation at 1 and 3.5 atmospheres upon blood gas transport, cerebral circulation and cerebral metabolism. J Appl Physiol. 1953; 5 (9): 471–86. https://doi.org/10.1152/jappl.1953.5.9.471.
64. Torbati D., Church D.F., Keller J.M., Pryor W.A. Free radical generation in the brain precedes hyperbaric oxygen-induced convulsions. Free Radic Biol Med. 1992; 13 (2): 101–6. https://doi.org/10.1016/0891-5849(92)90070-w.
65. Chavko M., Auker C.R., McCarron R.M. Relationship between protein nitration and oxidation and development of hyperoxic seizures. Nitric Oxide. 2003; 9 (1): 18–23. https://doi.org/10.1016/s1089-8603(03)00045-4.
66. Butler F.K. Diving and hyperbaric ophthalmology. Surv Ophthalmol. 1995; 39 (5): 347–66. https://doi.org/10.1016/s0039-6257(05)80091-8.
67. Nichols C.W., Lambertsen C. Effects of high oxygen pressures on the eye. N Engl J Med. 1969; 281 (1): 25–30. https://doi.org/10.1056/NEJM196907032810106.
68. McMonnies C.W. Hyperbaric oxygen therapy and the possibility of ocular complications or contraindications. Clin Exp Optom. 2015; 98 (2): 122–5. https://doi.org/10.1111/cxo.12203.
69. Dotsenko E.A., Salivonchyk D.P. Present-day role of hyperbaric oxygenation in the therapy of cardiovascular diseases. Health and Ecology Issues. 2010; 3: 58–64 (in Russ.). https://doi.org/10.51523/2708-6011.2010-7-3-11.
70. Dekleva M., Neskovic A., Vlahovic A., et al. Adjunctive effect of hyperbaric oxygen treatment after thrombolysis on left ventricular function in patients with acute myocardial infarction. Am Heart J. 2004; 148 (4): E14. https://doi.org/10.1016/j.ahj.2004.03.031.
71. Tang X.P., Tan M., Zhang T., et al. Effects of early hyperbaric oxygen therapy on clinical outcome in postoperative patients with intracranial aneurysm. Undersea Hyperb Med. 2011; 38 (6): 493–501.
72. Kukshina A.A., Kotelnikova A.V., Turova E.A., et al. Hyperbaric oxygenation in the muilimodality therapy of COVID-19-associated emotional burnout in physicians. Doctor.Ru. 2022; 21 (4): 47–52 (in Russ.). https://doi.org/10.31550/1727-2378-2022-21-4-47-52.
73. Doenyas-Barak K., Catalogna M., Kutz I., et al. Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: a prospective, randomized, controlled trial. PLoS One. 2022; 17 (2): e0264161. https://doi.org/10.1371/journal.pone.0264161.
74. Feng J.J., Li Y.H. Effects of hyperbaric oxygen therapy on depression and anxiety in the patients with incomplete spinal cord injury (a STROBE-compliant article). Medicine. 2017; 96 (29): e7334. https://doi.org/10.1097/MD.0000000000007334.
75. Efrati S., Fishlev G., Bechor Y., et al. Hyperbaric oxygen induces late neuroplasticity in post stroke patients – randomized, prospective trial. PLoS One. 2013; 8 (1): e53716. https://doi.org/10.1371/journal.pone.0053716.
76. Hadanny A., Catalogna M., Yaniv S., et al. Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial. Sci Rep. 2022; 12 (1): 15233. https://doi.org/10.1038/s41598-022-19395-y.
77. Li X., Li J., Yang X., et al. Hyperbaric-oxygen therapy improves survival and functional outcome of acute severe intracerebral hemorrhage. Arch Med Res. 2017; 48 (7): 638–52. https://doi.org/10.1016/j.arcmed.2018.03.001.
78. Sarabhai T., Mastrototaro L., Kahl S., et al. Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial. Diabetologia. 2023; 66 (1): 57–69. https://doi.org/10.1007/s00125-022-05797-0.
79. Ma L., Yong L., Yun Z. Clinical effects of hyperbaric oxygen on hypothyroidism after 131I therapy. J Radioimmunol. 2006; 19 (4): 333–5.
80. Henk J.M., Smith C.W. Radiotherapy and hyperbaric oxygen in head and neck cancer. Interim report of second clinical trial. Lancet. 1977; 2 (8029): 104–5. https://doi.org/10.1016/s0140-6736(77)90117-9.
81. Annane D., Depondt J., Aubert P., et al. Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized, placebo-controlled, double-blind trial from the ORN96 study group. J Clin Oncol. 2004; 22 (24): 4893–900. https://doi.org/10.1200/JCO.2004.09.006.
82. Watson E.R., Halnan K.E., Dische S., et al. Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the cervix. Br J Radiol. 1978; 51 (611): 879–87. https://doi.org/10.1259/0007-1285-51-611-879.
83. Chiles K.A., Staff I., Johnson-Arbor K., et al. A double-blind, randomized trial on the efficacy and safety of hyperbaric oxygenation therapy in the preservation of erectile function after radical prostatectomy. J Urol. 2018; 199 (3): 805–11. https://doi.org/10.1016/j.juro.2017.10.016.
84. Niezgoda J.A., Cianci P., Folden B.W., et al. The effect of hyperbaric oxygen therapy on a burn wound model in human volunteers. Plast Reconstr Surg. 1997; 99 (6): 1620–5.
85. Millar I.L., Lind F.G., Jansson K.Å., et al. Hyperbaric oxygen for lower limb trauma (HOLLT): an international multi-centre randomised clinical trial. Diving Hyperb Med. 2022; 52 (3): 164–74. https://doi.org/10.28920/dhm52.3.164-174.
86. Ersoz F., Arikan S., Sari S., et al. Effect of hyperbaric oxygen treatment on pilonidal disease surgery. Undersea Hyperb Med. 2016; 43 (7): 821–5.
87. Belyaeva K.L., Didenko N.V., Zagrekov V.I., et al. The effects of antioxidants and hyperbaric oxygenation at severe thermal injury: a prospective study. Bulletin of Rehabilitation Medicine. 2024; 23 (1): 8–22 (in Russ.). https://doi.org/10.38025/2078-1962-2024-23-1-8-22.
88. Simanic I., Teofilovski M., Paspalj D., et al. Hyperbaric oxygenation accelerates prosthetic rehabilitation of lower limb amputees. Undersea Hyperb Med. 2013; 40 (3): 289–97.
89. Leitman M., Fuchs S., Tyomkin V., et al. The effect of hyperbaric oxygen therapy on myocardial function in post-COVID-19 syndrome patients: a randomized controlled trial. Sci Rep. 2023; 13 (1): 9473. https://doi.org/10.1038/s41598-023-36570-x.
90. Hadanny A., Zilberman-Itskovich S., Catalogna M., et al. Long term outcomes of hyperbaric oxygen therapy in post covid condition: longitudinal follow-up of a randomized controlled trial. Sci Rep. 2024; 14 (1): 3604. https://doi.org/10.1038/s41598-024-53091-3.
91. Catalogna M., Sasson E., Hadanny A., et al. Effects of hyperbaric oxygen therapy on functional and structural connectivity in post-COVID-19 condition patients: a randomized, sham-controlled trial. Neuroimage Clin. 2022; 36: 103218. https://doi.org/10.1016/j.nicl.2022.103218.
92. Huang D., Li K., Zheng X., Liu L. Hyperbaric oxygen therapy: an effective auxiliary treatment method for large jaw cysts. Int J Med Sci. 2021; 18 (16): 3692–6. https://doi.org/10.7150/ijms.57360.
93. Wu X., Chen S., Li S., et al. Oxygen therapy in patients with retinal artery occlusion: a meta-analysis. PLoS One. 2018; 13 (8): e0202154. https://doi.org/10.1371/journal.pone.0202154.
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Miryutova N.F., Gruzdeva D.A. Hyperbaric oxygenation in rehabilitation medicine: application, action mechanisms, and effectiveness. Journal of Medical Rehabilitation. 2025;3(1):36-50. (In Russ.) https://doi.org/10.17749/2949-5873/rehabil.2025.38
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