rehabРеабилитологияJournal of Medical Rehabilitation2949-58732949-5881IRBIS Publishing House (IRBIS LLC)10.17749/2949-5873/rehabil.2024.14rehab-21Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESАдаптационные резервы у детейAdaptation reserves in childrenБыковщенкоГ. К.BykovshchenkoG. К.

Быковщенко Георгий Константинович

Ул. Трубецкая, д. 8/2, Москва 119048

Georgiy K. Bykovshchenko

8/2 Trubetskaya Str., Moscow 119048

gbk3004@yandex.ruhttps://orcid.org/0000-0002-3908-0381КотоваО. В.KotovaО. V.

Котова Ольга Владимировна - к.м.н., доцент.

Ул. Мусы Джалиля, д. 40, Москва 115573; ул. Миклухо-Маклая, д. 6, Москва 117198

Olga V. Kotova - PhD, Assoc. Prof.

40 Musa Dzhalil Str., Moscow 115573; 6 Miklukho-Maklay Str., Moscow 117198

https://orcid.org/0000-0002-7629-3773АкарачковаЕ. С.AkarachkovaE. S.

Акарачкова Елена Сергеевна - д.м.н., чл.-корр. РАЕН

Ул. Мусы Джалиля, д. 40, Москва 115573; ул. Лесная, д. 8, Московская обл., Истринский р-н, с. Павловская Слобода 143581

Elena S. Akarachkova - Dr. Sci. Med., Corr. Member of RANN.40 Musa Dzhalil Str., Moscow 115573; 8 Lesnaya Str., Moscow Region, Istra District, Pavlovskaya Sloboda 143581

Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет им. И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияSechenov UniversityRussian FederationМеждународное общество «Стресс под контролем»; Федеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов»РоссияInternational Society “Stress under Control”; Peoples' Friendship University of RussiaRussian FederationМеждународное общество «Стресс под контролем»; Реабилитационный центр RehalineРоссияInternational Society “Stress under Control”; Rehaline Rehabilitation CenterRussian Federation20241009202422216226Copyright © Быковщенко Г.К., Котова О.В., Акарачкова Е.С., 20242024Быковщенко Г.К., Котова О.В., Акарачкова Е.С.Bykovshchenko G.К., Kotova О.V., Akarachkova E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rehabilitology.com/jour/article/view/21Актуальность

Актуальность. Продолжительное течение хронических заболеваний, некоторые виды лечения, а также отдельные социальные факторы оказывают существенное стрессовое воздействие на пациентов молодого возраста. Современные методы реабилитации направлены на восстановление функциональной активности организма и пополнение утраченных адаптационных резервов. Однако ключевые особенности адаптации детей к стрессовым нагрузкам не изучены полностью.

Цель

Цель: раскрыть ключевые особенности механизмов адаптации к стрессовым воздействиям у детей.

Материал и методы

Материал и методы. Поиск и отбор публикаций проводили с учетом рекомендаций PRISMA в научных базах данных PubMed/MEDLINE, ScienceDirect, Google Scholar и электронных библиотеках eLibrary, Cochrane Library, а также дополнительно в поисковых системах Яндекс и Google. Обнаружено 1825 публикаций, из которых после отбора 50 включено в обзор.

Результаты

Результаты. Отмечен низкий уровень адаптационных резервов у детей для сопротивления стрессовым воздействиям, среди ключевых причин которого – недостаточное количество минералов и микроэлементов, поступающих в организм с пищей. При этом снижение адаптационных возможностей зачастую проходит скрыто и требует пристального мониторинга. В качестве средств профилактики истощения и восстановления функциональной активности представлены рекомендации, позволяющие оказать ребенку поведенческую и психологическую поддержку. Дополнительно показана эффективность магнийсодержащих препаратов в восстановлении адаптационных резервов у детей.

Заключение

Заключение. Чрезмерные стрессовые нагрузки у детей и подростков оказывают пагубное влияние на их физическое и психическое благополучие, способность регулировать собственное поведение и могут быть причиной ряда хронических заболеваний во взрослом периоде жизни. Своевременно оказанная психологическая поддержка, контроль питания и нормализация биологических ритмов позволят существенно увеличить адаптационные резервы и снизить вероятность хронических заболеваний в дальнейшем, а также нагрузку на систему здравоохранения в целом.

Background

Background. Long-term chronic diseases, some types of treatment, and individual social factors have a significant stress impact on young patients. Existing rehabilitation methods are aimed at restoring body functional activity and replenishing lost adaptation reserves. However, the key features of children's adaptation to stress loads have not been fully disclosed.

Objective

Objective: to reveal the key features of adaptation mechanisms to stressful influences in children.

Material and methods

Material and methods. The search and selection of publications were carried out according to PRISMA recommendations in the scientific databases PubMed/MEDLINE, ScienceDirect, Google Scholar and the electronic libraries eLibrary, Cochrane Library. Additionally, a search was conducted in the search engines Yandex and Google. In total, 1825 publications were found. After selection, 50 of them were included in the review.

Results

Results. Low level of adaptive reserves in children to resist stress effects was identified, the key reasons for which are insufficient amounts of minerals and microelements coming into the body with food. The decrease in adaptive capacity often occurs hidden and requires close monitoring. Recommendations were presented as a means of preventing exhaustion and restoring functional activity, allowing for behavioral and psychological support for the child. Additionally, the effectiveness of magnesium-containing drugs in restoring adaptive reserves in children was shown.

Conclusion

Conclusion. Excessive stress loads in children and adolescents have a detrimental effect on their physical and mental well-being, ability to regulate own behavior and can cause a number of chronic diseases in adulthood. Timely psychological support, nutritional control and normalization of biological rhythms will significantly increase the adaptive reserves and reduce the likelihood of chronic diseases in future as well as the burden on the healthcare system in general.

Детиподросткиадаптациястресспрофилактикалечениебиоорганический магнийпидолат магнияцитрат магниясонрасстройства снафизическая активностьпитаниепсихологическая адаптацияChildrenteenagersadaptationstresspreventiontreatmentbioorganic magnesiummagnesium pidolatemagnesium citratesleepsleep disordersphysical activitynutritionpsychological adaptationАвторы заявляют об отсутствии финансовой поддержкиReferencesГалкина Н.Ю. Психологические методы профилактики стресса в современных условиях. Проблемы современного педагогического образования. 2018; 60-2: 403–7.Galkina N.Yu. Psychological methods of stress prevention in modern conditions. Problemy SOVREMENNOGO pedagogicheskogo OBRAZOVANIYA / Problems of Modern Pedagogical Education. 2018; 60-2: 403–7 (in Russ.).Некрасова М.М., Аширова С.А. Бобоха Б.А. и др. Оценка аллостатической нагрузки у водителей автобусов. Медицинский альманах. 2016; 4: 158–61.Nekrasova M.M., Ashirova S.A. Bobokha B.A., et al. Assessment of allostatic load in bus drivers. Medical Almanac. 2016; 4: 158–61 (in Russ.).Кузнецов С.Л., Капитонова М.Ю., Дегтярь Ю.В., Загребин В.Л. Стресс и нейроэндокринная система: современные морфофункциональные аспекты. Вестник Волгоградского государственного медицинского университета. 2008; 2: 10–5.Kuznetsov S.L., Kapitonova M.Yu., Degtyar Yu.V., Zagrebin V.L. Stress and the neuroendocrine system: modern morphological and functional aspects. Journal of Volgograd State Medical UNIVERSITY. 2008; 2: 10–5 (in Russ.).Шамухамедова Н.Ш. Артериальная гипертензия: долговременный стресс, патогенез и медикаментозная терапия. ColloquiumJournal. 2019; 3-2: 51–2.Shamukhamedova N.Sh. Arterial hypertension: long-term stress, pathogenesis and medical treatment. Colloquium-Journal. 2019; 3-2: 51–2 (in Russ.).Солопова А.Е., Идрисова Л.Т., Чуканова Е.М., Алипов В.И. Нейроиммунология в онкологии: воздействие стресса на болезнь. Врач. 2017; 9: 14–6.Solopova A.E., Idrisova L.T., Chukanova E.M., Alipov V.I. Neuroimmunology in oncology: impact of stress on disease. Vrach / The Doctor. 2017; 9: 14–6 (in Russ.).Овечкин А.М. Хирургический стресс-ответ, его патофизиологическая значимость и способы модуляции. Регионарная анестезия и лечение острой боли. 2008; 2 (2): 49–62.Ovechkin A.M. Surgical stress-response, its pathophysiological significance and methods of modulation. Regional Anesthesia and Acute Pain Management. 2008; 2 (2): 49–62 (in Russ.).Гуцол Л.О., Гузовская Е.В., Серебренникова С.Н., Семинский И.Ж. Стреcc (общий адаптационный синдром). Байкальский медицинский журнал. 2022; 1 (1): 70–80. https://doi.org/10.57256/29490715-2022-1-70-80.Gutsol L.O., Guzovskaiia E.V., Serebrennikova S.N., Seminskу I.Zh. Stress (general adaptation syndrome) Lecture. Baikal Medical Journal. 2022; 1 (1): 70–80 (in Russ.). https://doi.org/10.57256/2949-07152022-1-70-80.Dalmaz Y., Peyrin L., Sann L., Dutruge J. Age-related changes in catecholamine metabolites of human urine from birth to adulthood. J Neural Transm. 1979; 46 (2): 153–74. https://doi.org/10.1007/BF01250336.Dalmaz Y., Peyrin L., Sann L., Dutruge J. Age-related changes in catecholamine metabolites of human urine from birth to adulthood. J Neural Transm. 1979; 46 (2): 153–74. https://doi.org/10.1007/BF01250336.Vanaelst B., Huybrechts I., Michels N., et al. Hair minerals and metabolic health in Belgian elementary school girls. Biol Trace Elem Res. 2013; 151 (3): 335–43. https://doi.org/10.1007/s12011-012-9573-8.Vanaelst B., Huybrechts I., Michels N., et al. Hair minerals and metabolic health in Belgian elementary school girls. Biol Trace Elem Res. 2013; 151 (3): 335–43. https://doi.org/10.1007/s12011-012-9573-8.Rosanoff A., Weaver C.M., Rude R.K. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr REV. 2012; 70 (3): 153–64. https://doi.org/10.1111/j.1753-4887. 2011.00465.x.Rosanoff A., Weaver C.M., Rude R.K. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr REV. 2012; 70 (3): 153–64. https://doi.org/10.1111/j.1753-4887. 2011.00465.x.Громова О.А. Магний и пиридоксин: основы знаний. Новые технологии диагностики и коррекции дефицита магния. М.: Прототип; 2006: 176 с.Gromova O.A. Magnesium and pyridoxine: fundamentals of knowledge. New technologies for the diagnosis and correction of magnesium deficiency. Мoscow: Prototip; 2006: 176 pp. (in Russ.).Rowe W.J. Correcting magnesium deficiencies may prolong life. Clin INTERV Aging. 2012; 7: 51–4. https://doi.org/10.2147/CIA.S28768.Rowe W.J. Correcting magnesium deficiencies may prolong life. Clin INTERV Aging. 2012; 7: 51–4. https://doi.org/10.2147/CIA.S28768.Ковальчук В.К., Иванова И.Л. Особенности обеспеченности кальцием, магнием и фосфором населения в Приморском крае. Гигиена и санитария. 2011; 1: 61–6.Kovalchuk V.K., Ivanova I.L. The specific features of calcium, magnesium and phosphorus supply of the population in the Primorye Territory. Hygiene and Sanitation. 2011; 1: 61–6 (in Russ.).Demiral M., Kiral E., Dinleyici E.C., Simsek E. Evaluation of the hypothalamic-pituitary-adrenal axis in a paediatric intensive care unit. Acta Endocrinol. 2019; 15 (4): 466–71. https://doi.org/10.4183/aeb.2019.466.Demiral M., Kiral E., Dinleyici E.C., Simsek E. Evaluation of the hypothalamic-pituitary-adrenal axis in a paediatric intensive care unit. Acta Endocrinol. 2019; 15 (4): 466–71. https://doi.org/10.4183/aeb.2019.466.Pickering G., Mazur A., Trousselard M., et al. Magnesium status and stress: the vicious circle concept revisited. Nutrients. 2020; 12 (12): 3672. https://doi.org/10.3390/nu12123672.Pickering G., Mazur A., Trousselard M., et al. Magnesium status and stress: the vicious circle concept revisited. Nutrients. 2020; 12 (12): 3672. https://doi.org/10.3390/nu12123672.Xu Z., Sheffield P.E., Hu W., et al. Climate change and children’s health – a call for research on what works to protect children. Int J ENVIRON Res Public Health. 2012; 9 (9): 3298–316. https://doi.org/10.3390/ijerph9093298.Xu Z., Sheffield P.E., Hu W., et al. Climate change and children’s health – a call for research on what works to protect children. Int J ENVIRON Res Public Health. 2012; 9 (9): 3298–316. https://doi.org/10.3390/ijerph9093298.Mariotti A. The effects of chronic stress on health: new insights into the molecular mechanisms of brain-body communication. Future Sci OA. 2015; 1 (3): FSO23. https://doi.org/10.4155/fso.15.21.Mariotti A. The effects of chronic stress on health: new insights into the molecular mechanisms of brain-body communication. Future Sci OA. 2015; 1 (3): FSO23. https://doi.org/10.4155/fso.15.21.Elwenspoek M.M.C., Kuehn A., Muller C.P., Turner J.D. The effects of early life adversity on the immune system. Psychoneuroendocrinology. 2017; 82: 140–54. https://doi.org/10.1016/j.psyneuen.2017.05.012.Elwenspoek M.M.C., Kuehn A., Muller C.P., Turner J.D. The effects of early life adversity on the immune system. Psychoneuroendocrinology. 2017; 82: 140–54. https://doi.org/10.1016/j.psyneuen.2017.05.012.Yoo Y.S., Popp J., Robinson J. Maternal distress influences young children’s family representations through maternal view of child behavior and parent-child interactions. Child Psychiatry Human DEVEL. 2014; 45 (1): 52. https://doi.org/10.1007/s10578-013-0377-7.Yoo Y.S., Popp J., Robinson J. Maternal distress influences young children’s family representations through maternal view of child behavior and parent-child interactions. Child Psychiatry Human DEVEL. 2014; 45 (1): 52. https://doi.org/10.1007/s10578-013-0377-7.Kvalevaag A.L., Ramchandani P.G., Hove O., et al. Paternal mental health and socioemotional and behavioral development in their children. Pediatrics. 2013; 131 (2): e463–9. https://doi.org/10.1542/peds.2012-0804.Kvalevaag A.L., Ramchandani P.G., Hove O., et al. Paternal mental health and socioemotional and behavioral development in their children. Pediatrics. 2013; 131 (2): e463–9. https://doi.org/10.1542/peds.2012-0804.Xerxa Y., Rescorla L.A., Shanahan L., et al. Childhood loneliness as a specific risk factor for adult psychiatric disorders. Psychol Med. 2023; 53 (1): 227. https://doi.org/10.1017/S0033291721001422.Xerxa Y., Rescorla L.A., Shanahan L., et al. Childhood loneliness as a specific risk factor for adult psychiatric disorders. Psychol Med. 2023; 53 (1): 227. https://doi.org/10.1017/S0033291721001422.Duckworth A.L., Kim B., Tsukayama E. Life stress impairs self-control in early adolescence. Front Psychol. 2013; 3: 608. https://doi.org/10.3389/fpsyg.2012.00608.Duckworth A.L., Kim B., Tsukayama E. Life stress impairs self-control in early adolescence. Front Psychol. 2013; 3: 608. https://doi.org/10.3389/fpsyg.2012.00608.Лифинцева А.А., Холмогорова А.Б. Семейные факторы психосоматических расстройств у детей и подростков. Консультативная психология и психотерапия. 2015; 1: 70–83.Lifintseva A.A., Kholmogorova A.B. Family factors of psychosomatic disorders in children and adolescents. Counseling Psychology and Psychotherapy. 2015; 1: 70–83 (in Russ.).Sanderson M., Mouton C.P., Cook M., et al. Adverse childhood experiences and chronic disease risk in the southern community cohort study. J Health Care Poor UNDERSERVED. 2021; 32 (3): 1384–402. https://doi.org/10.1353/hpu.2021.0139.Sanderson M., Mouton C.P., Cook M., et al. Adverse childhood experiences and chronic disease risk in the southern community cohort study. J Health Care Poor UNDERSERVED. 2021; 32 (3): 1384–402. https://doi.org/10.1353/hpu.2021.0139.Baumeister D., Akhtar R., Ciufolini S., et al. Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α. Mol Psychiatry. 2016; 21 (5): 642–9. https://doi.org/10.1038/mp.2015.67.Baumeister D., Akhtar R., Ciufolini S., et al. Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α. Mol Psychiatry. 2016; 21 (5): 642–9. https://doi.org/10.1038/mp.2015.67.Waszczuk M.A., Zavos H.M.S., Gregory A.M., Eley T.C. The phenotypic and genetic structure of depression and anxiety disorder symptoms in childhood, adolescence, and young adulthood. JAMA Psychiatry. 2014; 71 (8): 905–16. https://doi.org/10.1001/jamapsychiatry.2014.655.Waszczuk M.A., Zavos H.M.S., Gregory A.M., Eley T.C. The phenotypic and genetic structure of depression and anxiety disorder symptoms in childhood, adolescence, and young adulthood. JAMA Psychiatry. 2014; 71 (8): 905–16. https://doi.org/10.1001/jamapsychiatry.2014.655.Min M.O., Minnes S., Kim H., Singer L.T. Pathways linking childhood maltreatment and adult physical health. Child Abuse Negl. 2013; 37 (6): 361–73. https://doi.org/10.1016/j.chiabu.2012.09.008.Min M.O., Minnes S., Kim H., Singer L.T. Pathways linking childhood maltreatment and adult physical health. Child Abuse Negl. 2013; 37 (6): 361–73. https://doi.org/10.1016/j.chiabu.2012.09.008.Brill S.R., Patel D.R., MacDonald E. Psychosomatic disorders in pediatrics. Indian J Pediatr. 2001; 68 (7): 597–603. https://doi.org/10.1007/BF02752270.Brill S.R., Patel D.R., MacDonald E. Psychosomatic disorders in pediatrics. Indian J Pediatr. 2001; 68 (7): 597–603. https://doi.org/10.1007/BF02752270.Grover S., Avasthi A. Clinical practice guidelines for the management of depression in children and adolescents. Indian J Psychiatry. 2019; 61 (Suppl. 2): 226. https://doi.org/10.4103/psychiatry.IndianJPsychiatry_563_18.Grover S., Avasthi A. Clinical practice guidelines for the management of depression in children and adolescents. Indian J Psychiatry. 2019; 61 (Suppl. 2): 226. https://doi.org/10.4103/psychiatry.IndianJPsychiatry_563_18.Mindes G., Jewett J. Reviews of research: childhood stress. Childhood Educ. 1997; 73 (3): 172–3. https://doi.org/10.1080/00094056.1997.10522682.Mindes G., Jewett J. Reviews of research: childhood stress. Childhood Educ. 1997; 73 (3): 172–3. https://doi.org/10.1080/00094056.1997.10522682.McCarty R. The alarm phase and the general adaptation syndrome: two aspects of selye’s inconsistent legacy. In: Fink J. (Ed.) Stress: concepts, cognition, emotion, and behavior. Academic Press; 2016: 13–9. https://doi.org/10.1016/B978-0-12-800951-2.00002-9.McCarty R. The alarm phase and the general adaptation syndrome: two aspects of selye’s inconsistent legacy. In: Fink J. (Ed.) Stress: concepts, cognition, emotion, and behavior. Academic Press; 2016: 13–9. https://doi.org/10.1016/B978-0-12-800951-2.00002-9.Акарачкова Е.С., Блинов Д.В., Котова О.В. и др. Стресс у детей: как активировать адаптационные резервы у ребенка. Русский медицинский журнал. 2018; 26 (9): 45–51.Akarachkova E.S., Blinov D.V., Kotova O.V., et al. Stress in children: how to activate adaptive reserves in a child.russian Medical Journal. 2018; 26 (9): 45–51 (in Russ.).Hirshkowitz M., Whiton K., Albert S.M., et al. National Sleep Foundation’s updated sleep duration recommendations: final report. Sleep Health. 2015; 1 (4): 233–43. https://doi.org/10.1016/j.sleh.2015.10.004.Hirshkowitz M., Whiton K., Albert S.M., et al. National Sleep Foundation’s updated sleep duration recommendations: final report. Sleep Health. 2015; 1 (4): 233–43. https://doi.org/10.1016/j.sleh.2015.10.004.Акарачкова Е.С., Вершинина С.В., Котова О.В., Рябоконь И.В. Алгоритм диагностики, лечения и профилактики стресса и стресс-связанных расстройств у детей и подростков. Вопросы практической педиатрии. 2014; 9 (6): 24–31.Akarachkova E.S., Vershinina S.V., Kotova O.V., Ryabokon I.V. An algorithm of diagnosing, treatment and prevention of stress and stress-associated disorders in children and adolescents. Clinical Practice in Pediatrics. 2014; 9 (6): 24–31 (in Russ.).Акарачкова Е.С., Вершинина С.В., Котова О.В., Рябоконь И.В. Основы терапии и профилактики стресса и его последствий у детей и подростков. Вопросы современной педиатрии. 2013; 12 (3): 38–44. https://doi.org/10.15690/vsp.v12i3.679.Akarachkova E.S., Vershinina S.V., Kotova O.V., Ryabokon I.V. Bases of stress and its consequences therapy and prophylaxis in children and adolescents. Current Pediatrics. 2013; 12 (3): 38–44 (in Russ.). https://doi.org/10.15690/vsp.v12i3.679.Акарачкова Е.С. Дефицит магния у детей: лечить нельзя игнорировать. Где поставить запятую? Фарматека. 2021; 28 (9): 91–5. https://doi.org/10.18565/pharmateca.2021.9.91-95.Akarachkova E.S. Magnesium deficiency in children: to treat or ignore? Farmateka. 2021; 28 (9): 91–5 (in Russ.). https://doi.org/10.18565/pharmateca.2021.9.91-95.Магне В6® – препарат магния от усталости и стресса. URL: https://www.magneb6.com/ru-ru/Products/magne-b6 (дата обращения 10.03.2023).Magne B6® – magnesium preparation for fatigue and stress. Available at: https://www.magneb6.com/ru-ru/Products/magne-b6 (in Russ.) (accessed 10.03.2023).Магне В6® форте – препарат магния от усталости и стресса. URL: https://www.magneb6.com/ru-ru/Products/magneb6-forte (дата обращения 10.03.2023).Magne B6® forte – magnesium preparation for fatigue and stress. Available at: https://www.magneb6.com/ru-ru/Products/magneb6forte (in Russ.) (accessed 10.03.2023).Тутельян В.А., Спиричев В.Б., Суханов Б.П., Кудашева В.А. Микронутриенты в питании здорового и больного человека. М.: Колос; 2002: 424 с.Tutelyan V.A., Spirichev V.B., Sukhanov B.P., Kudasheva V.A. Micronutrients in the diet of a healthy and sick person. Мoscow: Kolos; 2002: 424 pp. (in Russ.).Торшин И.Ю., Громова О.А., Гусев Е.И. Механизмы антистрессового и антидепрессивного действия магния и пиридоксина. Журнал неврологии и психиатрии им С.С. Корсакова. 2009; 109 (11): 107–11.Torshin I.Iu., Gromova O.A., Gusev E.I. Mechanisms of antistress and antidepressive effects of magnesium and pyridoxine. S.S. KORSAKOV Journal of Neurology and Psychiatry. 2009; 109 (11): 107–11 (in Russ.).Guerrera M.P., Volpe S.L., Mao J.J. Therapeutic uses of magnesium. Am Fam Physician. 2009; 80 (2): 157–62.Guerrera M.P., Volpe S.L., Mao J.J. Therapeutic uses of magnesium. Am Fam Physician. 2009; 80 (2): 157–62.Геворгян А.П., Сибирская Е.В., Адамян Л.В., Арсланян К.Н. Первичная дисменорея девочек-подростков как предиктор развития недифференцированной дисплазии соединительной ткани. Проблемы репродукции. 2017; 23 (3): 77–85. https://doi.org/10.17116/repro201723377-85.Gevorgyan A.P., Sibirskaya E.V., Adamyan L.V., Arslanyan K.N. Primary dysmenorrhea in adolescent girls as a predictor of the development of undifferentiated connective tissue dysplasia.russian Journal of Human Reproduction. 2017; 23 (3): 77–85 (in Russ.). https://doi.org/10.17116/repro201723377-85.Evers S. Alternatives to beta blockers in preventive migraine treatment. NERVENARZT. 2008; 79 (10): 1135–6, 1138–40, 1142–3 (in German). https://doi.org/10.1007/s00115-008-2522-2.Evers S. Alternatives to beta blockers in preventive migraine treatment. NERVENARZT. 2008; 79 (10): 1135–6, 1138–40, 1142–3 (in German). https://doi.org/10.1007/s00115-008-2522-2.Grazzi L., Andrasik F., Usai S., Bussone G. Magnesium as a preventive treatment for paediatric episodic tension-type headache: results at 1-year follow-up. Neurol Sci. 2007; 28 (3): 148–50. https://doi.org/10.1007/s10072-007-0808-y.Grazzi L., Andrasik F., Usai S., Bussone G. Magnesium as a preventive treatment for paediatric episodic tension-type headache: results at 1-year follow-up. Neurol Sci. 2007; 28 (3): 148–50. https://doi.org/10.1007/s10072-007-0808-y.Halje K., Timpka T., Ekberg J., et al. Towards mHealth systems for support of psychotherapeutic practice: a qualitative study of researcher-clinician collaboration in system design and evaluation. Int J Telemed Appl. 2016; 2016: 5151793. https://doi.org/10.1155/2016/5151793.Halje K., Timpka T., Ekberg J., et al. Towards mHealth systems for support of psychotherapeutic practice: a qualitative study of researcher-clinician collaboration in system design and evaluation. Int J Telemed Appl. 2016; 2016: 5151793. https://doi.org/10.1155/2016/5151793.Muris P., Verweij C., Meesters C. The “anti-monster letter” as a simple therapeutic tool for reducing night-time fears in young children. BEHAVIOUR Change. 2003; 20 (4): 200–7. https://doi.org/10.1375/bech.20.4.200.29384.Muris P., Verweij C., Meesters C. The “anti-monster letter” as a simple therapeutic tool for reducing night-time fears in young children. BEHAVIOUR Change. 2003; 20 (4): 200–7. https://doi.org/10.1375/bech.20.4.200.29384.Tikotzky L., Sadeh A. The role of cognitive-behavioral therapy in behavioral childhood insomnia. Sleep Med. 2010; 11 (7): 686–91. https://doi.org/10.1016/j.sleep.2009.11.017.Tikotzky L., Sadeh A. The role of cognitive-behavioral therapy in behavioral childhood insomnia. Sleep Med. 2010; 11 (7): 686–91. https://doi.org/10.1016/j.sleep.2009.11.017.Громова О.А., Калачева А.Г., Сатарина Т.Е. и др. Влияние препарата Магне B6 на параметры стресса и когнитивную функцию при высоких психоэмоциональных нагрузках. Трудный пациент. 2008; 6 (12): 54–8.Gromova O.A., Kalacheva A.G., Satarina T.E., et al. The effect of Magne B6 on stress parameters and cognitive function under high psychoemotional loads. Trudnyj pacient / Difficult patient. 2008; 6 (12): 54–8 (in Russ.).Студеникин В.М., Турсунхужаева С.Ш., Звонкова Н.Г. и др. Магний и его препараты в психоневрологии. Эффективная фармакотерапия. 2012; 4-1: 8–12.Studenikin V.M., Tursunkhuzhaeva S.Sh., Zvonkova N.G., et al. Magnesium and its preparations in neuropsychiatry. EFFEKTIVNAYA farmakoterapiya / EFFECTIVE Pharmacotherapy. 2012; 4-1: 8–12 (in Russ.).Boyle N.B., Lawton C., Dye L. The effects of magnesium supplementation on subjective anxiety and stress – a systematic review. Nutrients. 2017; 9 (5): 429. https://doi.org/10.3390/nu9050429.Boyle N.B., Lawton C., Dye L. The effects of magnesium supplementation on subjective anxiety and stress – a systematic review. Nutrients. 2017; 9 (5): 429. https://doi.org/10.3390/nu9050429.

The authors declare that there are no conflicts of interest present.